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March 1967

Effect of Drugs on After-Nystagmus Induced by Lateral Vestibular Nucleus Stimulation

Author Affiliations

New Haven, Conn
From the Department of Anatomy, Yale University School of Medicine, New Haven, Conn. Dr. Yules is now at the Stanford University Medical School, Palo Alto, Calif.

Arch Otolaryngol. 1967;85(3):278-282. doi:10.1001/archotol.1967.00760040280008

A BRIEF TRAIN of electrical stimulation to the lateral vestibular nucleus to elicit nystagmus lasting for a considerable time poststimulation in cats has been reported by Yules and Gault.1 This response is quite predictable over several hours (Fig 1). Considering that this response exists poststimulation and that it is a predictable event, it appears that nystagmus elicited in this way might serve as a valuable assay procedure for antivertigo drugs.

The effects of medication on nystagmus have been evaluated previously using caloric, galvanic, or movement stimulation as the eliciting agent, but there have been no reports of the evaluation of medication on nystagmus elicited by central vestibular stimulation.

Methods  Experiments were performed on 29 cat preparations. Under ether anesthesia, the animals were tracheostomized, had a cephalic vein catheter inserted, underwent an occipital craniectomy, and had the spinal cord sectioned at C1. Wound edges were infiltrated with procaine and

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