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June 1967

Fibrous Dysplasia and Malignant Degeneration

Author Affiliations

From the Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, and the Department of Otolaryngology, Harvard Medical School, Boston.

Arch Otolaryngol. 1967;85(6):653-657. doi:10.1001/archotol.1967.00760040655012

IN THE current literature there is disagreement regarding the malignant degeneration of fibrous dysplasia. Certainly such an occurrence is rare, but a careful review of the literature yields 28 cases. In this paper we shall briefly review the important clinical aspects of fibrous dysplasia and its malignant potential, and we shall report an additional well-documented case of malignant degeneration. The treatment of fibrous dysplasia and bone sarcoma is reviewed as well.

Report of a Case  A 50-year-old white woman was admitted to the Massachusetts Eye and Ear Infirmary on Sept 23, 1964, with a questionable diagnosis of malignant degeneration of fibrous dysplasia of the right maxilla.At the age of 10 the patient had fallen and struck the right side of her face. Three years later she first noted swelling of the right side of her face which increased until the age of 19 (in 1933) when she underwent a

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