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September 1967

Enzyme Study of Wound Secretion in the Head and Neck

Author Affiliations

Zurich, Switzerland
From the Department of Otolaryngology and the Medical Policlinic, University of Zurich.

Arch Otolaryngol. 1967;86(3):332-340. doi:10.1001/archotol.1967.00760050334016

THE CLOSED WOUND negative pressure suction procedure is now widely used in head and neck surgery.1,2 However, little or no attention has been paid to the analysis of the fluid obtained by continuous wound drainage.

The aim of this study was to determine the activity of some intracellular enzymes in the secretion aspirated from a closed wound in the head and neck region. The enzyme assays concerned creatine phosphokinase (CPK), glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and lactic dehydrogenase (LDH). These enzymes occupy an increasingly important place in clinical medicine and present the advantage of being measured by already standardized methods.3-5 The enzyme CPK catalyzes the reversible reaction:

CPK adenosine triphosphate (ATP) + creatine ↔ adenosine diphosphate (ADP) + creatine phosphate in the muscle fibers. The enzymes GOT, GPT, and LDH are necessary for the energy metabolism of nearly all cells. The enzyme LDH favors the anaerobic glycolysis

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