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September 1967

Motion Sickness and the Reticular Formation

Author Affiliations

Palo Alto, Calif
From the Department of Surgery, Stanford-Palo Alto Medical Center, Palo Alto, Calif.

Arch Otolaryngol. 1967;86(3):355-356. doi:10.1001/archotol.1967.00760050357023

RECENT tests of motion sickness preparations indicate that a combination of atropine (0.6 mg) and amphetamine (10 mg) is more effective than many other commonly employed motion sickness preparations.1 Bradley2 has concluded that both atropine and amphetamine exert a profound effect on the reticular formation—that portion of the brain important in modulating sensory input.3 Investigators have studied the relationship of the reticular formation to the vestibular system4-7 and are searching for antimotion-sickness drugs which may exert an effect on the reticular system and thence on the vestibular system.8,9

It is appropriate to suggest caution in interpreting the effects of drugs on the reticular formation. Although Bradley employed amphetamine in "activating" the reticular formation and there appears to be a reticular or arousal component to the vestibular-nystagmus loop,10 unpublished data by the authors indicate that not only m-amphetamine,11 which has more vascular effects than

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