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October 1967

Profound Deafness in Otosclerosis

Author Affiliations

New York
From the Department of Otolaryngology, New York University School of Medicine, New York.

Arch Otolaryngol. 1967;86(4):382-386. doi:10.1001/archotol.1967.00760050384006

THE QUESTION of sensorineural hearing loss occurring in patients with otosclerosis has attracted the attention of many investigators. Although some, such as Guild1 and Glorig and Gallo,2 have found no greater incidence of sensorineural hearing loss in otosclerotic patients than in the general population, other workers3-6 have described clinically and anatomically examined patients with sensorineural hearing losses and otosclerotic lesions.

Altman et al6 made an extensive review of the histological findings described in the literature as possible causes of sensorineural hearing loss in patients with otosclerosis. These included: (1) venous stasis in the veins draining the cochlea; (2) irritation of the endosteal layer with production of fibrous tissue and bone in the scala tympani; (3) disintegration of the organ of Corti followed by ascending retrograde degeneration of the corresponding nerve fibers and ganglionic cells, this in turn being possibly due to toxic substances released by the

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