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October 1967

Vogt-Koyanagi-Harada Syndrome

Author Affiliations

From the Division of Otolaryngology, University of Tennessee Medical Units, Memphis.

Arch Otolaryngol. 1967;86(4):419-423. doi:10.1001/archotol.1967.00760050421012

THE VOGT-KOYANAGI-HARADA (VKH) syndrome is a relatively rare multisystem disease. This syndrome has been frequently reported by ophthalmologists; however, there has been a noticeable absence in the otolaryngologic literature. The most consistent finding is uveitis. It may also include alopecia, poliosis, vitiligo, and dysacousia.

Through the years the term dysacousia has been used with this syndrome when there were associated auditory problems. The true definition of the term is a condition in which ordinary sounds produce discomfort or pain.1 Although dysacousia does not apply to the patients we have seen, we will continue to use the term in this paper.

Vogt, in 1906, is given credit for the first description. In 1929, Koyanagi reviewed the literature which was composed of 16 cases, four of which were his own. He described headache, fever, bilateral anterior uveitis, dysacousia, vitiligo, poliosis, and alopecia. In 1926, Harada described five instances of the syndrome