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Article
November 1967

Kanamycin Dosage and Levels in Ear and Other Organs

Author Affiliations

Dusseldorf, Germany
From the Universitat Dusseldorf, HNO-Klinik, Dusseldorf, Germany.

Arch Otolaryngol. 1967;86(5):515-521. doi:10.1001/archotol.1967.00760050517009
Abstract

THE BASIC STREPTOMYCES antibiotics, streptomycin and kanamycin, are valuable and effective means in the hands of a physician. In many cases their use is indispensible, despite the danger of a toxic damage to the inner ear. The physician is therefore always faced with the weighty question of how these antibiotics are to be dosed in order to avoid possible damage.

It is difficult not only to estimate the amount of the individual dosage that may be prescribed but also the sequence of the injections. Even today, as with other antibiotics as well, treatment with daily injections prevails. Treatment only at intervals recommended by several authors, is only seldom tried. Berger and Wehrle,1 viewing the short duration of the blood level of antibiotics consider more frequent injections of every six hours necessary to the maintenance of therapeutically effective blood concentrations. This suggestion should be considered critically. In using toxic antibiotics

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