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November 1967

Human Larynx Injected With Teflon PasteHistologic Study of Innervation and Tissue Reaction

Arch Otolaryngol. 1967;86(5):550-561. doi:10.1001/archotol.1967.00760050552014

ONE OF US1 recently reviewed the development of intrachordal injection procedures in the treatment of chronic vocal disability. After having experimented with various substances,2,3 Arnold,4 in 1962, proposed the injection of Teflon granules suspended in glycerin. The present designation of the implant material is PTFE Paste for Injection (modified polytetrafluoro-ethylene, 50% weight in weight w/w in glycerin). This technique made it possible to revive the original idea published by Brünings5 in 1911 who injected paraffin for the correction of laryngeal paralysis. Numerous authors soon followed these suggestions and published their own experiences with the injection of granulated bone paste," silastic,7 Teflon,8-11 glycerin,12 and silicone.13 All these publications stressed the good functional results when suitable instances of this disability were treated with proper indication and correct techniques. Possible disappointments and their reasons have been discussed by Rubin.14

Further discussion of these

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