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November 1967

A Concept of Otolaryngologic Allergy

Author Affiliations

Salt Lake City
From the Division of Otorhinolaryngology, University of Utah College of Medicine.

Arch Otolaryngol. 1967;86(5):568-578. doi:10.1001/archotol.1967.00760050570016

AMONG THE MANY approaches to a study of allergy is a physiochemical view of the constantly changing activity of the tissues of patients so affected rather than the traditional antigen-antibody reactions. Any injury to tissue produces inflammation as a host response to localize and neutralize the effects of the damage. This response becomes allergy in a hereditarily select group. Although any sort of injury can produce inflammation or allergy, in the later instance the commonest cause is a product of the antigen-antibody reaction, hence its clinical importance.

There are two main types of allergic responses. The first is an immediate reaction. When specific antigens are introduced into the skin of an allergic individual a wheal is promptly produced. This is not the only reaction, for the antigen causes the formation of antibodies which effect the stress organs; smooth muscle, small blood vessels, and mucus glands as well as skin, so

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