ACINIC CELL carcinoma is a relatively rare tumor of the salivary glands, constituting from 2.3% to 7.7% of major salivary gland tumors1-4 and 12% of all malignant tumors of the major salivary glands.5 It appears to arise from the serous acinic portion of the glands, hence it is also called clear cell carcinoma or serous cell adenocarcinoma.1-3,6,7 However, Bhaskar8 considers the primary source of acinic cell carcinoma to be the ductal epithelium, which is pluripotent, rather than the acinic cells.
According to Godwin et al,2 all the acinic cell tumors of the major salivary glands so far reported have arisen in the parotid gland, the serous salivary gland. These tumors account for 15% to 17% of all malignant lesions of the parotid.3,9 Submandibular gland involvement of this tumor is rare.6,10 However, Shimada4 found in Japan that among seven cases of acinic cell
Suzuki H, Henderson R. Acinic Cell Carcinoma of the Sublingual Gland. Arch Otolaryngol. 1968;87(2):146–149. doi:10.1001/archotol.1968.00760060148009
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