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February 1968

Tonsillectomy: Morbidity and an Anti-inflammatory Agent

Author Affiliations

Panama, Republic of Panama
From the ENT Service, Social Security General Hospital, Panama, R.P.

Arch Otolaryngol. 1968;87(2):167-170. doi:10.1001/archotol.1968.00760060169015

THROUGHOUT the years, the otolaryngologist has been greatly concerned with the innumerable and varied complaints of patients following tonsillectomies. Taking this fact into consideration, we decided to use a potent anti-inflammatory agent with analgesic and antipyretic actions (oxyphenbutazone), in an attempt to determine its value in decreasing the morbidity after this surgical procedure.

The effectiveness of this drug to control edema and pain in laryngectomies, adenotonsillectomies, facial fractures of different types, and sinusectomies has been widely demonstrated by many authors: Catalano and Rossi,1 Connell et al,2 Miller et al,3 Neves Pinto,4 and Pinto Zepeda.5

Chemistry  The chemical composition of oxyphenbutazone is 1-phenyl-2(p-hydroxyphenyl)-3, 5-dioxo-4-butylpyrazolidine-monohydrate. It is a white powder, soluble in the alkaline medium of the duodenum. It is supplied in round sugar-coated tablets of 100 mg and in suppositories of 250 mg. The absorption is rapid and complete in the duodenum and it