IDENTIFICATION of the site of a lesion responsible for the hearing impairment associated with Rh incompatibility has been attempted through both histologic and audiologic studies. The findings from such investigations are contradictory. On one hand, human tissue studies suggest that icteric pigment deposits have resulted in dysfunction of the central auditory system.1 Such observations have led a number of professional workers to suggest that when a hearing loss occurs as a result of an Rh mismatch it is of the central type. In contrast, two investigators who employed a battery of differential audiological measures with a sample of Rh subjects have obtained profiles of results which are most like those seen in the presence of a cochlear lesion.1,2 However, Carhart3 has suggested that these results are actually the product of damage in the cochlear nuclei which cause behavior that:
... mimic cochlear lesions in many respects and which,
Matkin ND, Carhart R. Hearing Acuity and Rh Incompatibility: Electrodermal Thresholds. Arch Otolaryngol. 1968;87(4):383–388. doi:10.1001/archotol.1968.00760060385009
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