THE REPORT of the tissue removed from the middle ear and mastoid cavity of the original case was as follows: "a fragment of tissue measuring 9.7 mm covered with a squamous cell layer and immediately beneath this layer is an unusual tumor structure. Large tumor cells in groups are separated by dense fibrous tissue septa which contain dilated vessels. The groups of tumor cells are bordered by capillaries and form small alveolar structures. This alveolar arrangement of the tumor cells is not always distinct and they show compressed cord-like structures in places. The well-preserved tumor cells are large and polyhedral and their nuclei are rather small and not hyperchromatic. The large cytoplasm is frequently vacuolated and this vacuolization may obscure cell outlines. The oval nuclei are uniform, although there are areas in which the tumor cell nuclei vary in shape. There are no mitotic figures (Fig 1 and 2).
Rosenwasser H. Glomus Jugulare Tumors: II. Pathology. Arch Otolaryngol. 1968;88(1):6–10. doi:10.1001/archotol.1968.00770010008004
Otolaryngology in JAMA: Read the Latest
Customize your JAMA Network experience by selecting one or more topics from the list below.