THE EXISTENCE of some correlation between aging and a disturbance in calcium metabolism has long been suspected. It is generally known that in old people the bones tend to lose calcium while certain soft tissues (vessels, periarticular connective tissue, the crystalline lense, etc) appear to develop a particular affinity for calcium as manifested by the formation of massive calcium hydroxylapatite depositions at these sites.
It had silently been assumed, however, as a self-evident fact that the calcium deposition must be secondary to some "dystrophic" tissue damage that characterizes aging. In the course of our work on calciphylaxis1 we noted that, in young animals, the induction of certain types of calcium metabolism disturbances may result in a variety of changes characteristic of aging such as normally occur in aged individuals (eg, kyphosis, loss of hair, wrinkling of the skin with histologic changes reminiscent of senile elastosis, loss of muscle protein,
Hans Selye. Calciphylaxis and Aging. Arch Otolaryngol. 1968;88(3):296. doi:10.1001/archotol.1968.00770010298017