THIS PRESENTATION is in two parts: the theoretical basis for giving large doses of sodium fluoride to promote or encourage inactivation of the otosclerotic bone lesion; and our results to date in more than 150 patients treated with sodium fluoride.
First of all, let us correct the erroneous concept that otosclerosis is a lesion of increased bone density. It is the exact opposite: in its early and actively expanding stage it consists of one or more areas of localized osteoporosis with a spongy vascular type of bone poor in calcium and rich in connective tissue, cells, and blood vessels, replacing the ivory-dense bone of the normal labyrinthine capsule. We know that the spongy vascular otoporotic focus may spontaneously recalcify and again assume a density comparable to the normal capsular bone. Recalcified inactive otosclerosis is a little more common in older individuals, while active otoporotic lesions are somewhat more common in
Shambaugh GE. Sodium Fluoride for Inactivation of the Otosclerotic Lesion: Present Status. Arch Otolaryngol. 1969;89(2):381–382. doi:10.1001/archotol.1969.00770020383026
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