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March 1969

Droperidol and Fentanyl Citrate Compound as a Vestibular Depressant

Author Affiliations

Los Angeles

From the Department of Surgery, Division of Head and Neck Surgery, Otology Section, UCLA School of Medicine, Los Angeles and the Cedars-Sinai Medical Research Institute, Division of Otolaryngology, Cedars-Sinai Medical Center, Los Angeles.

Arch Otolaryngol. 1969;89(3):482-487. doi:10.1001/archotol.1969.00770020484008

MUCH attention has been directed in recent years to the growing field of active, potent drugs suggested for use in combating the symptoms of vertigo. Often such drugs have been employed previously for unrelated purposes, but their effects on the vestibular system have been observed only secondarily.

Droperidol and fentanyl citrate (Innovar), a drug originally introduced as an adjunct to general anesthesia,1 later was used to induce neuroleptanalgesia,2,3 the main characteristics of which are indifference, hypomotility, and analgesia. Neuroleptanalgesia is a state under which minor surgical procedures can be performed and thus has been advocated for endoscopic procedures.4 Dowdy et al5 observed that droperidol and fentanyl citrate depresses vestibular activity, and proposed its use in the treatment of Meniere's disease.

Fentanyl citrate is a narcotic, related structurally to meperidin and pharmacologically to both meperidin and morphine. Its chemistry has been described by Janssen.6 It is

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