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May 1969

Droperidol-Fentanyl Citrate in Equilibratory Disturbances

Author Affiliations

Ghent, Belgium
From the Department of Otorhinolaryngology, the University of Ghent, Ghent, Belgium.

Arch Otolaryngol. 1969;89(5):715-719. doi:10.1001/archotol.1969.00770020717009

Loss OF vestibular function has been observed during neuroleptanalgesia applied for otorhinolaryngological surgery.1 The absence or delayed appearance of nystagmus was especially striking during ultrasonic selective surgery of the vestibular apparatus in patients with Meniere's syndrome. This unexpected reaction could only be attributed to droperidol and fentanyl citrate, the drugs used for neuroleptanalgesia.

Droperidol is a rapid and short acting butyrophenone derivative2 and fentanyl citrate is a highly potent analgesic with a rapid onset and short duration of action.3 Both drugs were synthesized in the research laboratories of Janssen Pharmaceutica, Beerse (Belgium) and are supplied as a fixed combination of 2.5 mg of droperidol and 0.05 mg of fentanyl citrate/ml.

The use of these drugs in neuroleptanalgesia has been extensively described, but more recently their effectiveness as vestibular depressants has been reported.1,4-6

Selection of Patients and Dosage  Thirty-six patients (15 women and 21 men, age range

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