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June 1969

Granular Cell Myoblastoma of LarynxTwo Case Reports

Arch Otolaryngol. 1969;89(6):873-877. doi:10.1001/archotol.1969.00770020875014

GRANULAR cell myoblastoma is a benign lesion that continues to excite interest chiefly because of uncertainty as to its biological nature and precise histogenesis. It is rare in the larynx. Cracovaner and Opler,1 by adding their cases, totalled 42 reported cases of granular cell myoblastoma of the larynx, and this report adds two more.

Granular cell myoblastoma is known to occur in tissues of unrelated morphology and histology. While the tongue and mouth are sites of predilection, it may occur, besides in the larynx, in the skin, vulva, breast, esophagus, bronchus, appendix, rectum, anus, urinary bladder, gallbladder, and even in the pituitary stalk. There are several theories concerning its origin.

Muscle Theory.—Abrikossoff, in 1926, was first to describe these tumors when he reported his five cases. There were three on the tongue and one each on the lip and gastrocnemius muscle. He thought the tumors originated from degeneration