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June 1969

Technique of Serial Dilution Antigen Titration

Author Affiliations

Cheyenne, Wyo
From the Department of Surgery, the University of Colorado Medical School, Denver.

Arch Otolaryngol. 1969;89(6):887-891. doi:10.1001/archotol.1969.00770020889017

OVER 25 years ago, I began to treat allergic otolaryngologic problems, using several techniques. Well over a decade ago, I became interested in Rinkel's method of serial dilution antigen titration for inhalant allergies because of the superior results obtained by colleagues using this method. For the past 12 years, I have sponsored postgraduate courses in the Rinkel allergy technique.

Serial dilution antigen titration is a method, developed by the late Herbert J. Rinkel,1 by which the degree of sensitization to a specific antigen can be determined. It is based upon the interpretation of the skin response to injection of weak (nonreacting) dilutions, proceeding to stronger (reacting) dilutions of the antigen. The first test producing a wheal 2 mm larger than the preceding nonreacting wheal is considered the endpoint of reaction. It will be followed by a wheal 2 mm larger on the next stronger test dilution. Treatment based upon

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