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June 1969

Efficacy of Therapeutic Drugs for Vertigo

Author Affiliations

From the Department of Otolaryngology, Tokyo Women's Medical College, Tokyo. Dr. Uemura is currently at the Department of Neurology, the Mount Sinai School of Medicine, New York.

Arch Otolaryngol. 1969;89(6):895-901. doi:10.1001/archotol.1969.00770020897019

METHODS for ascertaining the therapeutic efficacy and the indications of drugs for vertigo can be divided into two main categories: (1) Whether improvement in clinical symptoms occurs when the drug is given to vertigo patients; (2) Whether the drug has a restraining effect on nystagmus induced experimentally by labyrinth stimulation.

Although humans are the object of both of these methods, the second has been used mainly for pharmaceutical studies on experimental animals. The advantage claimed by Jongkees and Philipszoon1 by the use of animal experiments is that relatively large dosages can be given compared to those used in human beings, thus allowing the application of the "all or nothing criterion"—not the suppression of nystagmus, but its complete disappearance can be made the standard of evaluation.

Much definite data may be obtained by this method, but the possibility of the difference in reaction of human beings and animals must

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