GRANULAR cell myoblastoma of the larynx is still a rare tumor. Less than 40 cases of laryngeal myoblastoma have been described so far. No case of laryngeal tumor has been reported in association with other neoplasms, benign or malignant.
This usually benign tumor has many interesting aspects in regards to its incidence, etiology, and the source of origin of the granular cell myoblasts. There is growing controversy in regards to its nature, histogenesis, and possible malignancy.
In 1854 Weber (cited by Balshi1) was the first to describe this tumor involving the tongue. Abrikossof (cited by Balshi1) is given credit for describing this tumor in 1926 when he reported five cases. Crane and Tremblay2 collected 157 cases of myoblastoma and added five of their own involving maxilla, mandible, tongue and subcutis, and anus. They did not reach any definite conclusions as to the histogenesis, but suggested evidence equally
Bhatnagar HN, Schwarz HJ. Granular Cell Myoblastoma of Larynx With Papillary Adenocarcinoma of Thyroid. Arch Otolaryngol. 1969;90(2):156–158. doi:10.1001/archotol.1969.00770030158012
Customize your JAMA Network experience by selecting one or more topics from the list below.