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August 1969


Arch Otolaryngol. 1969;90(2):260. doi:10.1001/archotol.1969.00770030262039

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Until the effectiveness of sodium fluoride has been definitely proven for the retardation or arrest of the otosclerotic bone lesion, we are advising it only when a polytome x-ray study reveals the presence of a decalcified focus in the cochlear capsule. To finally prove the value of sodium fluoride for promoting recalcification of such a lesion, there will need to be a controlled series of patients with similar decalcified foci who have not received the medication. Such a study is in progress but will not be completed for two or three years.

Experiences to date strongly suggest that sodium fluoride, in appropriate dosage, does promote recalcification of an actively expanding otosclerotic lesion in at least one third of the cases. Arrest of the progressive nerve deterioration in such cases is hoped for but reversal of cochlear deterioration with improvement in hearing can not be expected.

Currently we are prescribing 40

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