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September 1969

Mineral Content of Ossicles in Otosclerosis

Author Affiliations

Bethesda, Md
From the Endocrinology Branch, National Heart Institute, Bethesda, Md.

Arch Otolaryngol. 1969;90(3):265-270. doi:10.1001/archotol.1969.00770030267004

THE measurement of the mineral content of the bones of the human skeleton has been a difficult and important problem. The difficulties of such measurements involving the ossicles of the middle ear are compounded by their small size, their inaccessibility, and the practical problem of obtaining adequate numbers of ossicles to sample. However, if such measurements could be made then information correlating changes in ossicular mineral content with various pathological processes affecting the ossicles might be obtained. In an effort to obtain such information the mineral content of the middle ear ossicles of patients with and without otosclerosis has been evaluated by a new technique for the measurement of bone density. The technique was developed initially for the evaluation of the bone mineral content of the human radius in vivo, by monenergetic photon beam transmission.1,2 We have used this technique with minor modifications to determine directly, for the first

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