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October 1969

Suppression of Alcohol Induced Nystagmus by Innovar: A Clinical Study

Author Affiliations

From the Division of Otolaryngology, University of Colorado Medical Center, Denver. Dr. Vancil is currently with the Medical Research Department, Mead Johnson Research Center, Evansville, Ind.

Arch Otolaryngol. 1969;90(4):482-488. doi:10.1001/archotol.1969.00770030484014

AN EFFECTIVE drug for the treatment of Meniere's disease and other vestibular problems would be an important addition to the present day therapeutic armamentarium of the physician. A report of the drug Innovar (droperidol and fentanyl citrate) being used with good results in patients with Meniere's disease recently appeared in the literature.1 Because of the unpredictable remissions and exacerbations, it is difficult to evaluate whether or not a drug has genuinely altered the natural course of Meniere's disease. The following study was performed in order to determine the effect of Innovar on nystagmus induced by ethanol in normal human volunteers.

Methods  Subjects.—Ten well-motivated volunteer subjects, five women and five men, age 20 to 30 years, were selected after careful screening. All subjects were in excellent health as determined by history, physical examination, urinaylsis, complete blood cell count (CBC), blood urea nitrogen (BUN), serum glutamic oxaloacetic transaminase (SGOT), bilirubin,

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