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October 1969

Benign Lymphoepithelial Lesion of the Parotid Gland: Mikulicz's Disease

Author Affiliations

Petah Tikva, Israel
From the Ear, Nose, and Throat Department (Dr. Schindel) and the Department of Radiotherapy (Dr. Levie), Beilinson Medical Center, Tel Aviv University Medical School, Petah Tikva, Israel.

Arch Otolaryngol. 1969;90(4):496-499. doi:10.1001/archotol.1969.00770030498017

THIS tumor-like disease has been described under different names: lymphoepithelioma,1 adenolymphoma,2 and other terms such as chronic inflammation, lymphocytic tumor, adenoma-lymphomatosum, Mikulicz disease, and solid adenolymphoma. Whether this is an inflammatory or neoplastic disease is a problem which has yet to be solved. Godwin3 proposed the term "benign lymphoepithelial lesion" because some of the manifestations of this pathologic process would seem to be of a fundamentally inflammatory nature, whereas others would seem more appropriately neoplastic. This process may be present in scattered foci, it may diffusely involve the entire gland, be localized to a single, nonencapsulated focus, or, finally, be circumscribed and encapsulated.4 In some cases, more than one, or all, of these different forms may be present simultaneously, or may follow one another.

Microscopically, these lesions are composed predominantly of lymphoid tissue, with smaller and larger epithelial islands scattered throughout. The lymphoid tissue is regular

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