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November 1969

Sulfur Metabolism in Otosclerosis

Author Affiliations

São Paulo, Brazil
From the Department of Otorhinolaryngology, Clinical Hospital of the Faculty of Medicine, University of São Paulo, Brazil.

Arch Otolaryngol. 1969;90(5):572-573. doi:10.1001/archotol.1969.00770030574008

OTOSCLEROSIS is characterized by a progressive loss of hearing, due to the ankylosis of the stapes, and is somewhat related to pregnancy, sex, age, and race factors.1

The biochemical blood pattern in otosclerosis is apparently within the normal range; an exception, however, is made for the significantly high sulfate content.2

A progressive increase of the sulfate concentrations of the blood serum of pregnant women was reported.3 This was also known to be the beginning of deafness or the increase of loss of hearing of women with otosclerosis during pregnancy.1,4

The accumulation of radioactive sulfate by cultures of the hearing ossicles has also been reported.5

In order to obtain information on the sulfur metabolism in otosclerosis, the present work was undertaken.

Material and Methods  Four patients with otosclerosis were admitted to the Otolaryngologic Clinic and, during six five-day periods of balance, the sulfur contents of

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