[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 18.206.12.79. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
November 1969

Succinic Dehydrogenase in the Pigeon Ampulla

Author Affiliations

Philadelphia
From the Otological Research Laboratory, Presbyterian-University of Pennsylvania Medical Center, Philadelphia.

Arch Otolaryngol. 1969;90(5):574-580. doi:10.1001/archotol.1969.00770030576009
Abstract

THE ENERGY requirements of cells are largely provided by carbohydrate metabolism. Because differences in energy requirements of tissues within the membranous labyrinth may provide information about physiological function, a considerable amount of work has been devoted to localization of enzymes involved in the metabolism of glucose. Most of the energy derived from the metabolism of glucose is liberated during the Krebs cycle.

The Krebs cycle is the second part of a two-stage process of glucose metabolism. During the first stage glycogen is catabolized to pyruvate by phosphorylation. The pyruvate then enters the Krebs cycle where it is oxidized and ultimately converted to carbon dioxide and water. This dehydrogenation process takes place in several steps, each step being controlled by a specific enzyme. One of the essential steps in this sequence of reactions is the dehydrogenation of succinate by the enzyme succinic dehydrogenase (SDH). The hydrogen in this step is transferred

×