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November 1969

Multiple Sclerosis After X-radiation: Activation by Treatment of Metastatic Glomus Tumor

Author Affiliations

USA; USA; USA, Washington, DC
From the Walter Reed General Hospital and the Armed Forces Institute of Pathology, Washington, DC.

Arch Otolaryngol. 1969;90(5):617-621. doi:10.1001/archotol.1969.00770030619017

GLOMUS JUGULARE tumors are uncommon, and metastasis from such tumors has been reported in only ten other cases.1 Multiple sclerosis or other demyelinating disorders have not been described in association with these tumors, but there are two reports of disseminated plaques of demyelination that developed after radiation.2,3

This report presents a clinicopathologic study of a 34-year-old woman with a metastasizing glomus jugulare tumor and multiple sclerosis activated following high-voltage x-radiation. The foci of active demyelination were limited to the fields of radiation and closely resembled the changes associated with the early delayed effects of radiation as described by Lampert and his associates.2,3 In their studies, however, preexisting multiple sclerosis was not apparent, so the present case appears to be unique as the first example of multiple sclerosis activated by x-radiation.

Report of a Case  A 34-year-old white woman was initially hospitalized on Sept 7, 1966, and died

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