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January 1970

Parotid Gland of Sjögren's Syndrome

Author Affiliations

Chiba City, Chiba, Japan
From the Department of Otolaryngology, Chiba University School of Medicine, Chiba, Japan. Dr. Ishikawa is currently at the Allergy Research Laboratory, Buffalo General Hospital, Buffalo, NY.

Arch Otolaryngol. 1970;91(1):64-70. doi:10.1001/archotol.1970.00770040090013

THE Sjögren syndrome is an autoimmune disease1 which occurs most commonly in middle-age women. Sjögren's syndrome is characterized by keratoconjunctivitis sicca, arthritis, and dry mouth with or without enlargement of the parotid gland. A number of cases have been reported since Sjögren published his monograph in 1933,2 and a number of the clinical manifestations have been added.3-6 Steroid hormone therapy is the most effective upon the recurrent swelling of the parotid gland and keratoconjunctivitis sicca. This syndrome is not fatal, commonly. Few patients of this disease, however, also have rheumatoid cardiac disease or systemic lupus erythematosus which leads to death. Histological changes of the parotid gland are characterized by atrophy of acini and ducts, and by infiltration of lymphocytes, plasma cells, and eosinophils.7 In order to establish the definite diagnosis of this syndrome, in an early stage, biopsy of the parotid gland and the immunoserological reactions found

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