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February 1970

Granular Cell Myoblastoma of the Larynx

Author Affiliations

From the Section of Otolaryngology, Department of Surgery, University of Chicago.

Arch Otolaryngol. 1970;91(2):125-127. doi:10.1001/archotol.1970.00770040195004

GRANULAR cell myoblastoma was first described by Abrikossoff in 1926.1 The principal sites of occurrence of this lesion are the tongue, skin, subcutaneous tissue, breast, and respiratory tract. To our knowledge, involvement of the larynx has been described in only 45 patients at the time of this writing2-4; five additional cases have recently been seen at the University of Chicago Hospitals and Clinics.

The pathogenesis of the lesion is uncertain. The consensus of opinion favors the concept of a neoplastic origin; others support a nonneoplastic nature. Virus-like particles have been described,5 and a parasitic infestation has been implicated.6 Some authors postulate a degeneration-regeneration phenomenon occurring in mature striated muscle cells.1-7 Support has also been given to a histiocytic lesion, inflammatory or xanthomatous in nature.8-11

The histogenesis is similarly in dispute; the histiocyte,8-11 embryonic myoblast,12-15 fibroblast,16 and Schwann cells17-20 have all

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