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May 1970

Labial Pits—Cleft Lip and/or Palate Syndrome: A Report of Five New Families

Author Affiliations

Iowa City
From the Department of Otolaryngology and Maxillofacial Surgery (Drs. McConnel and Lawrence), and the Department of Pediatrics, Dr. Zellweger, University of Iowa, Iowa City. Dr. McConnel is currently at the Department of Otolaryngology and Maxillofacial Surgery, Northwestern University Medical School, Chicago, and Dr. Lawrence is currently at the Department of Otolaryngology, University of Texas Medical Branch, Galveston, Tex.

Arch Otolaryngol. 1970;91(5):407-411. doi:10.1001/archotol.1970.00770040601002

Genealogical and clinical findings of five new families with the syndrome of pits of the lower lips and clefts of lip and palate (PiCLCP) suggest that the condition is transmitted as an autosomal dominant trait with—in most instances—complete penetrance of the mutant gene. The phenotype manifestations vary considerably from case to case. A satisfactory cosmetic result can be achieved by total excision of the pits provided one preserves the vermilion border.

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