Genealogical and clinical findings of five new families with the syndrome of pits of the lower lips and clefts of lip and palate (PiCLCP) suggest that the condition is transmitted as an autosomal dominant trait with—in most instances—complete penetrance of the mutant gene. The phenotype manifestations vary considerably from case to case. A satisfactory cosmetic result can be achieved by total excision of the pits provided one preserves the vermilion border.
McConnel FMS, Zellweger H, Lawrence RA. Labial Pits—Cleft Lip and/or Palate Syndrome: A Report of Five New Families. Arch Otolaryngol. 1970;91(5):407–411. doi:10.1001/archotol.1970.00770040601002
Otolaryngology in JAMA: Read the Latest
Customize your JAMA Network experience by selecting one or more topics from the list below.