The syndrome of gustatory sweating following radical neck dissection appeared in six patients, five of whom had sweating occur on the neck skin, and one, on the facial skin. The most typical location is in the submandibular area on the upper skin flap. The aberrant regeneration of autonomic nerve fibers after injury best explains the abnormal sweating. The fact that nerves to the sweat glands are functionally cholinergic although anatomically sympathetic is the critical factor in establishing this abnormal pathway and allowing neurohumoral transmission of nerve impulses.