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July 1970

Ototoxicity of New and Potent Diuretics: A Preliminary Study

Author Affiliations

Durham, NC
From the Division of Otolaryngology, Department of Surgery, Duke University Medical Center, Durham, NC. Dr. Mathog is now a major with the US Air Force Medical Corps, Otolaryngology Branch, USAF School of Aerospace Medicine, Brooks Air Force Base, San Antonio, Tex.

Arch Otolaryngol. 1970;92(1):7-13. doi:10.1001/archotol.1970.04310010033002

The ototoxicity of ethacrynic acid and furosemide is studied in cats utilizing round window electrodes and light microscopy. Both diuretics produce a primary depression of the cochlear microphonic and action potential with almost complete recovery in one hour. Depending upon the dosage and method of administration a severe secondary depression may develop with ethacrynic acid. This delayed depression is associated with the appearance of outer hair cell degeneration in the basal and middle coils of the cochlea.

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