The ototoxicity of ethacrynic acid and furosemide is studied in cats utilizing round window electrodes and light microscopy. Both diuretics produce a primary depression of the cochlear microphonic and action potential with almost complete recovery in one hour. Depending upon the dosage and method of administration a severe secondary depression may develop with ethacrynic acid. This delayed depression is associated with the appearance of outer hair cell degeneration in the basal and middle coils of the cochlea.
Mathog RH, Thomas WG, Hudson WR. Ototoxicity of New and Potent DiureticsA Preliminary Study. Arch Otolaryngol. 1970;92(1):7–13. doi:10.1001/archotol.1970.04310010033002
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