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July 1970

Ototoxicity of New and Potent DiureticsA Preliminary Study

Arch Otolaryngol. 1970;92(1):7-13. doi:10.1001/archotol.1970.04310010033002

The ototoxicity of ethacrynic acid and furosemide is studied in cats utilizing round window electrodes and light microscopy. Both diuretics produce a primary depression of the cochlear microphonic and action potential with almost complete recovery in one hour. Depending upon the dosage and method of administration a severe secondary depression may develop with ethacrynic acid. This delayed depression is associated with the appearance of outer hair cell degeneration in the basal and middle coils of the cochlea.