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August 1970

Metaphyseal Dysplasia: Genetic and Otolaryngological Aspects

Author Affiliations

St. Louis
From St. Louis University School of Medicine (Drs. Gladney and Monteleone), and Genetic Clinic, Cardinal Glennon Memorial Hospital for Children, St. Louis (Dr. Monteleone).

Arch Otolaryngol. 1970;92(2):147-153. doi:10.1001/archotol.1970.04310020045011

Metaphyseal dysplasia demonstrated by clinical, audiological, and roentgenological studies, occurred in seven members of a large kindred. Serial audiograms, roentgenograms, and close clinical reexamination over a ten-year period were obtained and described. In contradistinction to previous reports, the disease in this family is progressive, inherited by an autosomal dominant mode, and manifests itself in all members by hearing loss first presenting to the otolaryngologist.

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