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February 1971

Biochemical Studies of Otosclerosis: Urinary Steroids

Author Affiliations

Dayton, Ohio
From the Otological Research Laboratories, Good Samaritan Hospital, Dayton, Ohio (Dr. Soifer, Mr. Holdsworth, and Miss Weaver); Columbia University College of Physicians and Surgeons, New York (Dr. Waltner); and the Department of Physiological Chemistry and Department of Surgery, Ohio State University, Columbus (Dr. Endahl).

Arch Otolaryngol. 1971;93(2):128-131. doi:10.1001/archotol.1971.00770060214004

Average urinary excretion of 17-ketosteroids in 32 patients with otosclerosis was the same as in 29 nonotosclerotic patients. The average urinary excretion of 17-hydroxysteroids in 31 patients with otosclerosis also did not differ from 28 nonotosclerotic patients. Preliminary results suggest that excretion of estrogens is elevated in the otosclerotic male compared to the nonotosclerotic male. Based on urinary excretion it is concluded that a change in the levels of androgens or corticoids is not involved in otosclerosis. Estrogens may be an influencing factor, however.

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