From 1954 through 1968, 108 cases of invasive carcinoma of the floor of the mouth were treated. Primary tumor only occurred in 50% and 46.3% had regional node involvement. At least 70% of those with localized disease were salvaged, and comparable results were obtained by irradiation and surgery in patients with lesions measuring 2 cm or less. Treatment was successful in only 25% of cases with regional nodes. Preoperative irradiation had no significant effect. No patients with either bilateral or fixed cervical node involvement were salvaged.
Kolson H, Spiro RH, Rosewit B, Lawson W. Epidermoid Carcinoma of the Floor of the MouthAnalysis of 108 Cases. Arch Otolaryngol. 1971;93(3):280–283. doi:10.1001/archotol.1971.00770060418010
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