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April 1971

Reconstruction of the Mandible: Use of a Homograft Combined With Autogenous Bone and Marrow

Author Affiliations

USN; USN; USN, Bethesda, Md
From the Otolaryngology Service, Naval Hospital (Dr. deFries), the Oral Surgery Department, US Naval Dental School (Dr. Marble), and the Tissue Bank, Naval Medical Research Institute (Dr. Sell), Bureau of Medicine and Surgery, Navy Department, Research Tasks Nos. MR005.02.001A and M4305.03.3001. Dr. Marble is now at the Oral Surgery Service, Veterans Hospitals, and the School of Dentistry, Medical College of Georgia, Augusta.

Arch Otolaryngol. 1971;93(4):426-432. doi:10.1001/archotol.1971.00770060618014

Reconstruction of large avulsive defects of the mandible has often been characterized by instability and poor cosmetic and functional results. Animal experiments have demonstrated that freeze-dried rat bone grafts infused with the recipient's bone marrow were indistinguishable from fresh autogenous grafts. With similar grafts in humans, it should be possible to replace any portion of the mandible with a graft that is closely matched by size and shape to the particular defect. In our patient a large mandibular defect was replaced, using a banked human mandible which had been hollowed out and filled with autogenous cancellous red-marrow-containing bone. The graft was successful, and an excellent cosmetic and functional result was achieved. There is radiographic evidence of regeneration of new, normal bone in this patient, who has been followed closely for nearly two years.

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