Reconstruction of large avulsive defects of the mandible has often been characterized by instability and poor cosmetic and functional results. Animal experiments have demonstrated that freeze-dried rat bone grafts infused with the recipient's bone marrow were indistinguishable from fresh autogenous grafts. With similar grafts in humans, it should be possible to replace any portion of the mandible with a graft that is closely matched by size and shape to the particular defect. In our patient a large mandibular defect was replaced, using a banked human mandible which had been hollowed out and filled with autogenous cancellous red-marrow-containing bone. The graft was successful, and an excellent cosmetic and functional result was achieved. There is radiographic evidence of regeneration of new, normal bone in this patient, who has been followed closely for nearly two years.
deFries HO, Marble HB, Sell KW. Reconstruction of the Mandible: Use of a Homograft Combined With Autogenous Bone and Marrow. Arch Otolaryngol. 1971;93(4):426–432. doi:10.1001/archotol.1971.00770060618014
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