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Article
June 1971

CANCER THERAPY-Reply

Author Affiliations

Mount Sinai School of Medicine Department of Otolaryngology New York 10029

Arch Otolaryngol. 1971;93(6):638. doi:10.1001/archotol.1971.00770060940020

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Abstract

Dr. Goldman and I agree that it is not necessarily true that demonstration of the incorporation of thymidine into the new DNA of cancer cells demonstrates that these cells will necessarily divide and continue replicating DNA. No study is currently capable of a teleologic description of what cells will do. We would need a crystal ball for this purpose. However, as we indicated in the articles on tritiated thymidine studies, ie, "The Intranuclear Tracer," "Cell Viability", and "Pre-Operative Irradiation," (Laryngoscope, vol 78, No. 8, August 1967) and "Tritiated Thymidine Studies of Radiated Laryngeal Cancer," the manufacture of DNA is probably the most important function that a cell can subserve. No cell division would be possible without first accomplishing DNA synthesis and we feel that it is a reasonable criterion of current viability. As to what will happen to the cell following DNA synthesis and one generation of cell division,

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