[Skip to Navigation]
July 1971

Effect of Labyrinthectomy on Gastric Secretion

Author Affiliations

Memphis, Tenn
From the departments of anatomy (Dr. Schapiro), otolaryngology and maxillofacial surgery (Drs. Gross and Nakamura), medicine (Dr. Wruble), (Division of Gastroenterology) and surgery (Dr. Britt), University of Tennessee Medical Units, and the Research Laboratories, VA Hospital, Memphis, Tenn.

Arch Otolaryngol. 1971;94(1):36-39. doi:10.1001/archotol.1971.00770070072007

Gastric cannulae were placed in the stomach of four dogs. The acid output per hour was determined after (1) the subcutaneous injection of 0.1 mg histamine (base), (2) the subcutaneous injection of 1.0 mg histamine (base), and (3) the intravenous injection of 1.0 unit/kg of insulin. The pepsin concentration was also determined after the intravenous injection of 1.0 unit/kg of insulin. Following bilateral labyrinthectomy the gastric secretory studies were repeated at intervals. There was a depression of the acid output and the pepsin concentration in all dogs, to all the gastric stimuli, over a four-month period.

Add or change institution