Squamous cell carcinoma and granular cell myoblastoma occuring in the same larynx are presented. A frequent feature of myoblastomas is pseudoepitheliomatous hyperplasia. This irregular proliferation of the epithelium may be mistaken for early invasive carcinoma. Cases are reviewed from the literature in which granular cell myoblastomas had been misdiagnosed as squamous cell carcinomas. Multiple biopsies are advocated in tumors of the head and neck at the time of direct laryngoscopy. It is felt that more accurate programs of therapy can be planned with careful mapping of the involved sites. An incidental benefit may be the discovery of an early second lesion.
Goldstein A, Thaler S, Rozycki D. Granular Cell Myoblastoma and Carcinoma of the Larynx. Arch Otolaryngol. 1971;94(4):366–368. doi:10.1001/archotol.1971.00770070558015
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