Intraepithelial carcinoma of the mucosal surfaces can extend to involve the underlying mucus glands. The nature of this involvement remains within the realm of the preinvasive, carcinoma in situ. The larynx is endowed with a rich supply of mucus glands. Total laryngeal organ sections were employed to study two cases of carcinoma in situ that featured prominent glandular involvements. It can be difficult to distinguish this lesion from invasive cancer; furthermore, invasion may well occur from the glandular elements, while the lesions in the overlying mucosa remains preinvasive. Parallels to uterine cervical lesions are drawn and discussed regarding the present concepts of classification and therapy of laryngeal cancer. The topography of mucus glands in a specific anatomical location seems an important determinant to the mode of spread of cancer in that location.
Bridger GP, Nassar VH. Carcinoma in Situ Involving the Laryngeal Mucus Glands. Arch Otolaryngol. 1971;94(5):389–400. doi:10.1001/archotol.1971.00770070635002
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