A double-blind trial was conducted using heparin to prevent thrombosis in 2-mm rabbit neck veins joined by the Nakayama technique. Four groups of rabbits were used and heparin administered to the experimental groups as a local wash, a stat intravenous injection, and a stat intravenous injection plus one week of intramuscular heparin. Results show a similar and highly significant statistical diminution in thrombosis rates, when using the latter two methods. Adoption of the technique utilizing one intravenous injection of heparin preoperatively is suggested for future use in reconstructive surgery if autologous tissue based on a free vascular pedicle is to be employed.
Elcock HW, Fredrickson JM. The Effect of Heparin on Thrombosis at Microvenous Anastomotic Sites. Arch Otolaryngol. 1972;95(1):68–71. doi:10.1001/archotol.1972.00770080116013
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