In five patients, carcinomata appeared in the postcricoid and hypopharyngeal regions from 7 to 12 years after successful therapeutic irradiation for carcinoma of the endolarynx. These tumors were considered to be radiation-induced. Treatment consisted of cytostatic and palliative drugs in one case, irradiation in two cases, and surgical intervention in two cases. Irradiation appeared to be ineffective in sterilizing the tumor and the treatment of choice in such cases would seem to be surgical. The relevant literature and the problem of etiology are briefly discussed.
Schindel J, Castoriano IM. Late-Appearing (Radiation-Induced) Carcinoma: Carcinomas of the Postcricoid and Hypopharyngeal Regions Following Successful Irradiation Therapy for Laryngeal Carcinoma. Arch Otolaryngol. 1972;95(3):205–210. doi:10.1001/archotol.1972.00770080347004
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