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March 1972

Late-Appearing (Radiation-Induced) Carcinoma: Carcinomas of the Postcricoid and Hypopharyngeal Regions Following Successful Irradiation Therapy for Laryngeal Carcinoma

Author Affiliations

Petah Tikva, Israel
From the Ear, Nose, and Throat Department, Beilinson Medical Center, University of Tel Aviv Medical School, Petah Tikva, Israel.

Arch Otolaryngol. 1972;95(3):205-210. doi:10.1001/archotol.1972.00770080347004

In five patients, carcinomata appeared in the postcricoid and hypopharyngeal regions from 7 to 12 years after successful therapeutic irradiation for carcinoma of the endolarynx. These tumors were considered to be radiation-induced. Treatment consisted of cytostatic and palliative drugs in one case, irradiation in two cases, and surgical intervention in two cases. Irradiation appeared to be ineffective in sterilizing the tumor and the treatment of choice in such cases would seem to be surgical. The relevant literature and the problem of etiology are briefly discussed.

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