In serous otitis media the mucosa of the middle ear seems to be altered. Biopsies taken at the round window niche showed cylindrical cells, some of them with cilia. These cells were rich in cytoplasm, some were vacuolated, and they contained AB-PAS-positive material. Infiltration by inflammatory cells was found only in clinically infected ears with purulent fluid. The fluid in the middle ear in serous otitis media seems in the main to consist of a transudate. Mucus from epithelium can be mixed with it and makes the transudate viscous.
Gundersen T, Glück E. The Middle Ear Mucosa in Serous Otitis Media. Arch Otolaryngol. 1972;96(1):40–44. doi:https://doi.org/10.1001/archotol.1972.00770090078009
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