The effectiveness of pseudoephedrine hydrochloride (a sympathomimetic) and triprolidine hydrochloride (an antihistamine) was tested on the dog's eustachian tube. Triprolidine appeared to be an effective antihistamine at clinical doses. It significantly reduced the tube's response to exogenous histamine. Pseudoephedrine increased the patency of the eustachian tube. However, tachyphylaxis was one of the drugs' prominent features. Tachyphylaxis occurred most often when given intravenously or intra-arterially and least often when applied topically. The significance of tachyphylaxis to drug prescribing is discussed.
Dempsey JE, Jackson RT. Pseudoephedrine and the Dog's Eustachian Tube. Arch Otolaryngol. 1972;96(3):216–219. doi:https://doi.org/10.1001/archotol.1972.00770090338002
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