Twenty-four patients with unusual forms of laryngeal and pharyngeal edema were categorized pathophysiologically into four groups: increased capillary pressure, lowered plasma osmotic pressure, impaired lymphatics, and increased capillary permeability to proteins. The latter category comprises diseases that either affect the integrity of the capillary wall or have a metabolic defect that increases capillary diffusion. Diabetes mellitus and collagen disease produce defects of the capillary wall which can result in edema. Angioneurotic edema and urticarial reactions are believed to result from a biochemical abnormality that allows excess vascular fluid to pass into the interstitial space. There were three patients with laryngeal edema in whom no underlying disease could be found. Resolution of edema usually was achieved whenever the treatment of the underlying disease was possible; however, some improvement also was noted with use of nonspecific medications such as steroids, phenylbutazone, and epineph
Calcaterra TC. Laryngeal and Pharyngeal Edema of Obscure Origin. Arch Otolaryngol. 1972;96(4):341–345. doi:10.1001/archotol.1972.00770090517008
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