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Article
December 1972

A Comparative Study of the Ototoxicity of Tobramycin and Gentamicin

Author Affiliations

Portland, Ore
From the University of Oregon Medical School, Department of Otolaryngology, Portland, Ore.

Arch Otolaryngol. 1972;96(6):505-512. doi:10.1001/archotol.1972.00770090783003
Abstract

Dose response experiments were conducted on guinea pigs comparing the toxic liability of tobramycin and gentamicin on cochlear electrophysiology and histology. Parallel curves were obtained for the effect on the alternating current cochlear potential and hair cell destruction. In all cases the most damaging effect was produced by gentamicin.

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