Histologically benign but locally destructive, slowly growing, hypervascular neoplasm arises from glomus jugulare, erodes petrous bone, invades middle ear and mastoid, involves cranial nerves VII to XII inclusive, and may extend further either intracranially as cerebellopontine angle tumor or extracranially as nasopharyngeal or upper cervical mass. Distant metastases are rare.
Cases in which tumor is limited to middle ear and mastoid can be cured by surgical extirpation, an operation often complicated by severe hemorrhage from tumor. For more advanced cases with involvement of petrous bone, radiation therapy in dose range of 4,000 to 5,000 rads administered in a four- to six-week period will effect improvement of symptoms with reduction of tumor size and vascularity, but not necessarily destruction of the tumor. Radiation therapy is also treatment of choice for recurrences after surgery.
Sidney M. Silverstone. Radiation Therapy of Glomus Jugulare Tumors. Arch Otolaryngol. 1973;97(1):43–48. doi:10.1001/archotol.1973.00780010047012
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