Based on the clinical experience obtained over a five-year-period studying more than 500 cases, the present state of the problem of tympanic transplants is defined. It is emphasized that in such implants the collagenous fibers are dead and the fibrocytes progressively loosened during the preservation in 2-(ethylmercurithio) -5-benzoxazolcarboxylic acid (Cialit). For this reason these grafts are immunologically inert.
From a review of the different ways to improve the results, it appears that better results can be obtained by larger covering of the graft or by an increase of the tensile strength of the graft. It is concluded that in addition to restoring tympanic membranes and giving a new superstructure to a deficient ear drum, the main advantage of the technique is that ossicles can be implanted in a very satisfactory way.
Marquet J, Schepens P, Kuijpers W. Experiences With Tympanic Transplants. Arch Otolaryngol. 1973;97(1):58–66. doi:10.1001/archotol.1973.00780010062015
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